中国品牌·永利yl23411no1(官方VIP认证)-Best Platform

个人简介


   陈填烽,暨南大学教授,国家杰出青年基金获得者、国家863青年科学家、霍英东青年教师奖获得者。现任永利yl23411no1副院长,附属第一医院纳米诊疗研究所所长、广东省纳米化学创新药物工程技术研究中心主任。研究方向为硒纳米医学与疾病精准诊疗应用。相关研究成果在Signal Transduction and Targeted Therapy(IF 38)、Matter、Sci Adv、J Am Chem Soc、Angew Chem Int Ed、Adv Funct Mater、Biomaterials等本领域IF>10期刊发表论文80篇,封面论文40篇,h-index 72,连续入选“中国高被引学者”榜单、全球顶尖10万科学家榜单。申报中国专利90项,授权国家发明专利43项,实现技术成果转化13项,实现了纳米硒GMP吨级生产,并开展多中心临床研究。以第一完成人获得2020年高等学校科学研究优秀成果奖技术发明二等奖、2020年中国抗癌协会科技二等奖、2018年中华医学科技奖青年科技奖、2018广东省自然科学二等奖等科技奖励。

   课题组网页:https://chembio.jnu.edu.cn/main.psp



学习经历


· 08/2005–06/2008,香港中文大学生物系博士(化学生物学、细胞生物学)

· 09/2003–06/2005,暨南大学化学系硕士(生物无机化学)

· 09/1999–06/2003,暨南大学化学系学士(应用化学)



工作经历


  

· 01/2018至今,   暨南大学附属第一医院纳米诊疗研究所所长、教授(博导)

· 12/2016至今,   中国品牌·永利yl23411no1(官方VIP认证)-Best Platform副院长、教授(博导)

· 10/2010至今,   暨南大学化学系教授(博士生导师)

· 09/2015至今,   广东省纳米化学创新药物工程技术研究中心 主任

· 12/2008-09/2010,暨南大学化学系副教授(博士生导师) 



研究方向


   化学创新药物:陈填烽教授团队一直围绕恶性肿瘤精准诊疗中的关键科学问题,以临床问题为导向开展微量元素硒的化学设计与创新药物开发,深度揭示了硒的形态/结构/功能之间的密切联系,提升了纳米硒的功能性与成药性,实现了肿瘤多模态靶向治疗。突破了纳米硒工业化生产的技术瓶颈,打通了基础研究与临床实践之间的壁垒,促进纳米硒迅速转化应用于肿瘤临床治疗,推动了纳米技术创新发展,在国际上引领了硒纳米医学领域的快速发展。



主要论文



 

代表性论文

IF

1              

Haoqiang Lai, Ligeng Xu,* Chang Liu,   Sujiang Shi, Yalin Jiang, Yangyang Yu, Bo Deng, Tianfeng Chen*. Universal   selenium nanoadjuvant with immunopotentiating and redox-shaping activities   inducing high-quality immunity for SARS-CoV-2 vaccine. Signal Transduction   and Targeted Therapy, 2023, 8: 88.

38.12

2              

Fengzhi Zhao, Wei Huang, Lizhen He, Shiqing   Nie, Zhiting Sun, Tianfeng Chen*, Haiyan Yin*, Jianfu Zhao*. Reversing   lung cancer radioresistance by hyperpermeable tellurium nanotherapeutics via   remodeling tumor microenvironment, Nano Today, 2023, 50, 101819

 

18.962

3              

Chang Liu, Run Lin, Haoqiang Lai, Fen Pi,   Qian Xue, Tianfeng Chen*, Weiling He*. Thermosensitive selenium hydrogel   boosts antitumor immune response for hepatocellular carcinoma   chemoradiotherapy, Nano Today, 2023, 50, 101823.

18.962

4              

Zushuang Xiong#, Hao Lin#,   Hong Li, Binghua Zou, Bin Xie, Yanzi Yu, Lizhen He*, Tianfeng Chen*. Chiral   Selenium Nanotherapeutics Regulates Selenoproteins to Attenuate   Glucocorticoid-induced Osteoporosis, Advanced Functional Materials. 2023,    DOI: 10.1002/adfm.202212970

19.924

5              

Lizhen He, Jianfu Zhao, Hongjun Li, Bin   Xie, Ligeng Xu, Guanning Huang, Ting Liu, Zhen Gu*, Tianfeng Chen*, Metabolic   reprogramming of NK cells by black phosphorus quantum dots potentiates cancer   immunotherapy, Advanced Science, 2023, in press.

 

17.521

6              

Guanlin Li#, Sicheng Wu#, Wenzhe Chen#,   Xiaolu Duan, Xinyuan Sun, Shujue Li, Zanlin Mai, Wenzheng Wu, Guohua Zeng*,   Hongxing Liu*, Tianfeng Chen*. Designing intelligent nanomaterials to achieve   highly sensitive diagnoses and multimodality therapy of bladder cancer. Small   Methods, 2023, 2201313.

 

15.367

7              

Shuya Pan, Guanning Huang, Zhengwei Sun,   Xin Chen, Xinli Xiang, Wenxiao Jiang, Yanchao Xu, Tianfeng Chen*, Xueqiong   Zhu*. X-ray-responsive Zeolitic Imidazolate Framework-capped Nanotherapeutics   for Cervical Cancer-targeting Radiosensitization. Advanced Functional   Materials. 2023, in press

 

19.924

8              

Mingkai   Chen, Wenqiang Cao, Junping Wang, Fei   Cai, Liwen Zhu, Li Ma,* and Tianfeng Chen*. Selenium Atom-Polarization Effect   Determines TrxR-Specific Recognition of Metallodrugs. J Am Chem Soc, 2022,   144, 45, 20825–20833.

16.383

9              

Wenxiao   Jiang, Zhongyang Zhang, Miaomiao Ye, Shuya Pan, Guanning Huang, Tianfeng   Chen, Xueqiong Zhu, Morphology-directed   radiosensitization of MoSe2 nanoplatforms for promoting cervical cancer   radiotherapy, Nano Today,2022, 46, 101598.

18.962

10          

Binhua Zou#, Zushuang Xiong#,   Lizhen He*, Tianfeng Chen*. Reversing Breast Cancer Bone Metastasis by Metal   Organic Framework-Capped Nanotherapeutics via Suppressing Osteoclastogenesis,   Biomaterials, 285,121549.

15.304

11          

Zhenhuan Song, Ting Liu, Haoqiang Lai,   Xiaofeng Meng, Liu Yang, Jianyu Su*, and Tianfeng Chen*. A Universally   EDTA-Assisted Synthesis of Polytypic Bismuth Telluride Nanoplates with a   Size-Dependent Enhancement of Tumor Radiosensitivity and Metabolism In Vivo, ACS   Nano, 2022, 16, 3, 4379-4396

 

18.027

12          

Jiang Ouyang, Qingyue Bu, Na Tao, Mingkai Chen,   Haijun Liu, Jun Zhou, Jinggong Liu, Bo Deng, Na Kong, Xingcai Zhang*,   Tianfeng Chen*, Yihai Cao, Wei Tao*. A Facile and General Method for   Synthesis of Antibiotic-Free Protein-based Hydrogel: Wound Dressing for the   Eradication of Drug-Resistant Bacteria and Biofilms. Bioactive Materials,   2022, 18,446-458.

 

16.874

13          

Xiaosheng   Liang#, Ting Liu#, Linpeng Li#, Jieli Li, Shufang Li, Ke Zeng, Chao Song, Tianfeng   Chen*, and Yi Zou*, Translational selenium nanotherapeutics counter-acts   multiple risk factors to improve surgery-induced cognitive impairment. Chemical   Engineering Journal2022, 441, 135984.

 

16.744

14          

Qi Chen#, Lizhen He#, Xiaoying Li, Ligeng   Xu* and Tianfeng Chen*. Ruthenium Complexes Boost NK Cell Immunotherapy via   Sensitizing Triple-negative Breast Cancer and Shaping Immuno-microenvironment,   Biomaterials, 2022, 281, 121371.

15.304

15          

Guanning Huang†, Jiankun Zang†, Lizhen He†,   Huili Zhu†, Jiarun Huang, Zhongwen Yuan, Tianfeng Chen*, Anding Xu*, Bioactive   Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in   Neurons under Ischemic Stroke, ACS Nano, 2022, 16,   1, 431–452.

 

18.027

16        

Wei Huang, Lizhen He*, Zhongyang Zhang, Sujiang Shi, and Tianfeng Chen*.   Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory   Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer, ACS   Nano, 2021, 15, 12, 20225–20241.

 

18.027

17          

Hui Yang#,   Chang Liu#, Yanjun Wu, Meng Yuan, Jiarun Huang, Yuhan Xia, Qinjie Ling, Peter   R. Hoffmann, Zhi Huang*, Tianfeng Chen*. Atherosclerotic   Plaque-targeted Nanotherapeutics Ameliorates Atherogenesis by Blocking   Macrophage-driven Inflammation, Nano Today,2022, 101351.

 

18.962

18          

Weiqiang Lin#, Hongxing Liu#, Lingwu Chen,   Junxing Chen, Dong Zhang, Qingqing Cheng, Fang Yang, Qinsong Zeng*, Tianfeng   Chen*. Pre-clinical MRI-guided intravesical instillation theranosis of   bladder cancer by tumor-selective oxygen nanogenerator, Nano Today,   2021, 38, 101124.

 

18.962

19          

Ting Liu, Xi Zhang, Lizhen He, Zehang Zhang,   Junmei Feng, Zhiming Lin*, Tianfeng Chen*. Specific Nanotherapeutics   for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus,   Chemical Engineering Journal2022, 133095.

16.744

20          

Runcong Liu, Yongjun Peng, Ligong Lu, Shaojun   Peng*, Tianfeng Chen* and Meixiao Zhan*, Near-Infrared Light-Triggered Nano-prodrug   for Cancer Gas Therapy, Journal of Nanobiotechnology, 2021, 19:443.

 

9.429

21          

Mingkai Chen, Xiaoting Huang, Huatian Shi, Jie   Lai, LiMa*, Tai-Chu Lau*, Tianfeng Chen*. Cr(V)–Cr(III) in-situ transition   promotes ROS generation to achieve efficient cancer therapy. Biomaterials,   2021, 276, 120991.

15.304

22          

Lizhen He#,   Guanning Huang#, Hongxing Liu, Chengcheng Sang, Xinxin Liu, Tianfeng Chen*. Highly bioactive   zeolitic imidazolate framework-capped nanotherapeutics for efficient reversal   of reperfusion-induced injury in ischemic stroke.Science   Advances, 2020; 6: eaay9751.

14.972

23          

Wei Huang,   Lizhen He, Jiang Ouyang, Qi Chen, Chuang Liu, Wei Tao*, and Tianfeng Chen*.   Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint   Blockade Immunotherapy. Matter, 2020, 3, 1725-1753.

 

19.967

24          

Zhongyang Zhang, Zhongmin Tang, Nika Farokhzad,   Tianfeng Chen,* and Wei Tao*. Sensitive, Rapid, Low-Cost, and   Multiplexed COVID-19 Monitoring by the Wireless Telemedicine Platform. Matter,   2020, 3, 1818–1831.

 

19.967

25          

Leung Chan#, Xiaodan Chen#, Pan Gao, Jun Xie,   Zhongyang Zhang, Jianfu Zhao, Tianfeng Chen*. Coordination-Driven   Enhancement of Radiosensitization by Black Phosphorus via Regulating Tumor Metabolism.   ACS Nano, 2021, 15, 2, 3047

 

18.027

26          

Jiang Ouyang, Ling Zhang, Leijiao Li, Zhongmin   Tang, Xiaoyuan Ji, Chan Feng, Na Tao, Na Kong, Tianfeng Chen*, You-Nian   Liu*, Wei Tao*. Cryogenic Exfoliation of 2D Stanene Nanosheets for Cancer Theranostics.   Nano-Micro Letters, 2021, 13:90.

 

23.655

27          

Ting Liu#, Ligeng Xu#, Lizhen He, Jianfu   Zhao, Zehang Zhang, Qi Chen, Tianfeng Chen*. Selenium Nanoparticles   Regulates Selenoprotein to Boost Cytokine-Induced Killer Cells-Based Cancer   Immunotherapy. Nano Today, 2020, 35, 100975.

 

18.962

28          

Zhuo Wang‡, Lizhen He‡, Bingqing Liu,Li-Peng Zhou, Li-Xuan Cai, Shao-Jun Hu, Xiao-Zhen Li, Zhikai Li, Tianfeng   Chen,* Xiaopeng Li,*Qing-Fu Sun*. Coordination-Assembled   Water-Soluble Anionic Lanthanide Organic Polyhedra for Luminescent Labeling   and Magnetic Resonance Imaging. J. Am. Chem. Soc., 2020, 142, 38, 16409–16419.   

 

16.383

29          

Hao-Yan Yin, Jiu-Jiao Gao, Xuemin Chen, Bin   Ma, Zi-Shu Yang, Juan Tang, Bing-Wu Wang,    Tianfeng Chen*, Chu Wang*, Song Gao, Jun-Long Zhang*. A Gallium(III)   Complex that Engages Protein Disulfide Isomerase A3 (PDIA3) as an Anticancer   Target. Angew Chem Int Edit, 2020, 59, 20147-20153.

16.823

30          

Liu, Chang; Lai, Haoqiang; Chen, Tianfeng*.   Boosting Natural Killer Cell-Based Cancer Immunotherapy with Selenocystine/Transforming   Growth Factor-Beta Inhibitor-Encapsulated Nanoemulsion. ACS Nano, 2020, 14, 9, 11067.

 

18.027

31          

Jing Wang, Yanzhou Chang, Hui Luo, Wenxiao Jiang,   Ligeng Xu, Tianfeng Chen*, Xueqiong Zhu*. Designing Immunogenic Nanotherapeutics   for Photothermal-Triggered Immunotherapy Involving Reprogramming Immunosuppression   and Activating Systemic Antitumor Responses. Biomaterials, 2020,   120153.

 

15.304

32          

Hongxing Liu†, Chaoming Mei†, Xuanru Deng,   Weiqiang Lin, Lizhen He, Tianfeng Chen*. Rapid visualizing and pathological   grading of bladder tumor tissues by simple nanodiagnostics, Biomaterials,   2021, 264, 120434.

 

15.304

33          

Zhennan   Zhao, Pan Gao, Li M* and Tianfeng   Chen*. A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy.   Chemical Science, 2020, 11, 3780 -   3789

9.969

34          

Lizhen He, Li-Xuan Cai, Meng-Hua Li, Guang-Lu   Zhang, Li-Peng Zhou, Tianfeng Chen*, Mei-Jin Lin* and Qing-Fu Sun*. Designing   a highly stable coordination-driven metallacycle for imaging-guided photodynamic   cancer theranostics, Chemical Science,   2020, 11, 7940-7949.

 

9.969

35          

JuanjuanLi, TianfengChen*.   Transition metal complexes as photosensitizers for integrated cancer theranostic   applications, Coordination Chemistry Reviews, 2020, 418, 213355.

24.833

36          

Yuanyuan You, Zhennan Zhao, Lizhen He, Zhibo   Sun, Dong Zhang, Changzheng Shi, Qingqing Cheng, Yiyong Liu, Liangping Luo, Tianfeng Chen*. Long-term Oxygen   Storage Nanosystem for Near-Infrared Light-Triggered Oxygen Supplies to   Antagonize Hypoxia-induced Therapeutic Resistance in Nasopharyngeal Carcinoma.   Advanced Functional Materials. 2020, 2002369.

19.924

37          

Yanyu   Huang, Yuanting Fu, Mengting Li, Dawei Jiang, Christopher   J. Kutyreff, Jonathan W. Engle, Xiaoli Lan, Weibo Cai*, Tianfeng Chen*. Chirality-driven transportation and oxidation   prevention by chiral selenium nanoparticles. Angew Chem Int Edit, 2020, 59, 4406-4414. Frontispiece

 

16.823

38          

Yanhong Duo#, Yanyu Huang#,   Weiyuan Liang#, Riming Yuan, Yang Li, Tianfeng Chen*, Han   Zhang*. Ultraeffective Cancer Therapy with an Antimonene-Based X-Ray Radiosensitizer.   Advanced Functional Materials. 2019, 1906010.

19.924

39          

Hongxing Liu, Weiqiang Lin, Lizhen He*, Tianfeng   Chen*. Radiosensitive Core/Satellite Ternary Heteronanostructure for   Multimodal Imaging-Guided Synergistic Cancer Radiotherapy. Biomaterials,   2020, 119545.

 

15.304

40          

Chengli Dai †, ZhengTang   †, Xiaoling Li, Tianfeng Chen*.   High-pressure homogenization and tailoring of size-tunable Ganoderma   lucidum spore oil nanosystem for enhanced anticancer therapy. Chemical   Engineering Journal, 2021, 406, 127125

16.744



承担课题



1. 

国家自然科学基金国家杰出青年科学基金项目:纳米放射医学,400万(822250252023/01-2027/12),项目主持人;

2. 

国家自然科学基金面上项目:硒代胱氨酸衍生物调控硒蛋白干预肿瘤多模态治疗的分子机制研究, 58万(321712962022/01-2025/12

3. 

万人计划青年拔尖人才项目:肿瘤靶向纳米药物的化学设计,160(W020701912018/01-2022/12),项目主持人;

4. 

国家自然科学基金面上项目:含硒金属配合物的靶向设计与抗肿瘤作用机制研究,218770492019/01/01-2022/12/3167万,项目主持人;

5. 

广东省基础与应用基础研究基金区域联合基金重点项目:基于功能化纳米硒的肿瘤放射免疫治疗新策略及其临床转化应用(2020B1515120043),2020/10-2023/09100万,项目主持人;

6. 

广东普通高校创新团队项目:粤港澳纳米化学创新药物研究团队,2019KCXTD008100万(2020/01-2022/12),项目主持人;

7. 

广州市产业技术重大攻关计划:新型靶向放疗增敏剂的研发(201902020013),2019/04-2022-03600万,项目主持人;

8. 

广东省促进经济高质量发展专项资金海洋经济发展项目:高纯度含硒藻蓝蛋白作为肿瘤化疗增敏剂的研发(GDOE2019A31),2019/05-2020/10100万,项目主持人;

9. 

国家高新技术研究发展计划(863计划)项目:基于肿瘤血管生成的纳米硒靶向设计与临床前评价(2014AA020538, 2014/01-2016/12, 115),项目主持人;

10. 

广东省自然科学杰出青年基金基于肿瘤血管生成的纳米硒靶向设计及其作用机制(S2013050014667, 2013/10-2017/10, 100),项目主持人;

11. 

教育部新世纪优秀人才支持计划:新型有机硒化合物对TRAIL 的增敏作用与分子机制(NCET 10-0119, 2011-201350)项目主持人;

12. 

国家自然科学基金面上项目:TrxR靶向性的新型硒杂环化合物及其抗肿瘤分子机制(21271002),项目主持人,2013/1-2016/1278万;

13. 

国家自然科学基金青年科学基金项目:新型硒杂环化合物通过p53信号转导通路诱导肿瘤细胞凋亡的分子机制研究(2010-2012, 18万,20901030),项目主持人;

14. 

广东省“扬帆计划”引进创新创业团队项目:天然右旋龙脑生物医药创新开发 (201312H05 , 2014/01-2018/12,300万),团队带头人;

15. 

广东省科技计划粤港联合创新领域项目,纳米硒抗肿瘤靶向药物的临床前研究,(2015/01-2017/09,150万,2014B050505012)),项目主持人;



讲授课程


   承担4门本科生、1门硕士及1门博士生理论课程的教学工作,主持广东省、市及大学等6项教改项目,荣获第十届暨南大学校级教育教学成果奖一等奖。



荣誉与奖励


· 2020年,高等学校科学研究优秀成果奖技术发明二等奖:纳米硒高效制备关键技术及其生物医药应用。

· 2020年,中国抗癌协会科技奖二等奖:金属药物的功能设计与肿瘤精准诊疗应用。

· 2018年,广东省自然科学二等奖:金属药物的功能设计与肿瘤诊疗应用。

· 2018年,中华医学科技奖青年科技奖:硒药物化学设计与肿瘤诊疗应用。

  


社会职务


   

     2021年-,《Journal of Nanobiotechnology》(影响因子9.429)副主编

     2021年-,《Nano Research》(影响因子10.269)编委

     2019年-,《Smart Materials in Medicine》编委

     2021年-,中国抗癌协会纳米肿瘤学专委会第三届委员

     2019年-,中国医药生物技术协会造影技术分会委员会委员